Friday, September 27, 2019

Types Of Hodgkin's Lymphoma: Complete Cancer Guide

What are the types of Hodgkin’s lymphoma?
Classic Hodgkin’s lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) are the two types of Hodgkin’s lymphoma. About 95% of all cases are classical (or classic) Hodgkin lymphoma.  Classical Hodgkin’s lymphoma is further dived into four subtypes.

(2) Is classical Hodgkin lymphoma curable?
Only about 20% cases of classical Hodgkin lymphoma can’t be cured with standard first-line chemotherapy. However, Classical Hodgkin lymphoma is considered a highly treatable cancer disease.

(3) What are the causes of classic Hodgkin lymphoma?
Causes of Classical Hodgkin’s lymphoma:
About 40% Hodgkin lymphoma are related to a past infection with the Epstein-Barr virus (EBV). EBV is a very common virus that infects B lymphocytes and can cause glandular fever.

This Article Is About: Types Of Hodgkin's Lymphoma       Reading Time:   3 Minutes


(4) What are the subtypes of classical Hodgkin’s lymphoma?
Types Of Classic Hodgkin's Lymphoma:
There are four sub-types of classic Hodgkin lymphoma:
  1. Nodular Sclerosing Classical Hodgkin Lymphoma NSCHL
  2. Mixed Cellularity Classical Hodgkin Lymphoma MCCHL
  3. Lymphocyte Rich Classical Hodgkin Lymphoma LRCHL
  4. Lymphocyte Depleted Classical Hodgkin Lymphoma LDCHL
(5) How are the types of Hodgkin’s lymphoma diagnosed?
Various types of Hodgkin’s lymphoma exist and their diagnosis is based on the types of cells involved in the disease and behavior. The type of lymphoma determines the treatment options of your disease.

Classical Hodgkin’s lymphoma is the more common type of Hodgkin’s lymphoma. People diagnosed with Classical Hodgkin’s lymphoma have large, abnormal cells named as Reed-Sternberg cells in their lymph nodes. The prognosis for MCCHL and LDCHL is worse than for NSCHL


(6) What is the survival rate for different types of Hodgkin’s lymphoma?
Different types of Hodgkin’s lymphoma grow and spread differently. They also need different remedies and methods to treat. The survival of patients with Hodgkin’s lymphoma also varies with the sub-type of Hodgkin’s lymphoma.
  • Classical Hodgkin’s lymphoma: 84.8%
  • Classical Hodgkin’s lymphoma not otherwise specified: 75.2%
  • Nodular lymphocyte predominant Hodgkin’s lymphoma: 95.3%
 
Hodgkin lymphoma types
Hodgkin lymphoma type
  1. Nodular Sclerosin Classical Hodgkin’s Lymphoma: 89.4%
  2. Lymphocyte Rich Classical Hodgkin’s Lymphoma: 87.1%
  3. Mixed Cellularity Classical Hodgkin’s Lymphoma: 80%
  4. Lymphocyte Depleted Classical Hodgkin’s Lymphoma: 56.6%
(7) What is the Incidence rate for different types of Hodgkin’s lymphoma?
The rates of incidence for different types of Hodgkin’s Lymphoma:
In developed countries, Classic Hodgkin’s lymphoma accounts for more than 9 in 10 cases of Hodgkin lymphoma.
  • (1) Classical Hodgkin’s Lymphoma (CHL)                        = 95%
  • (2) Nodular Lymphocyte Predominant Hodgkin’s Lymphoma (NLPHL)   = 5%
The incidence rate for subtypes of Classical Hodgkin’s Lymphoma is given below.
  1. Nodular Sclerosin Classical Hodgkin Lymphoma NSCHL           =    70%
  2. Mixed Cellularity Classical Hodgkin Lymphoma MCCHL             =    10% To 25%
  3. Lymphocyte Rich Classical Hodgkin Lymphoma LRCHL            =    1%
  4. Lymphocyte Depleted Classical Hodgkin Lymphoma LDCHL     =    1%


(8) Describe the various types of Hodgkin’s lymphoma?
What is Classic Hodgkin’s lymphoma?

(1) Classic Hodgkin’s lymphoma:
The cancer cells in classical hodgkin’s lymphoma are called Reed-Sternberg cells. Reed-Sternberg cells are an abnormal type of B lymphocyte. Enlarged lymph nodes in people with classical hodgkin’s lymphoma have a small number of Reed-Sternberg cells with a lot of normal immune cells surrounding them. These other immune cells cause most of the swelling in the lymph nodes of patient’s body. It accounts for 95% of all Hodgkin’s lymphoma types.

(9) What is Nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL)?
(2) Nodular lymphocyte predominant Hodgkin’s lymphoma:
Nodular lymphocyte-predominant Hodgkin’s lymphoma is much rarer type of Hodgkin’s lymphoma. It accounts for about 5% of Hodgkin’s lymphoma cases. It can occur in people of any age however NLPHL is most often diagnosed in middle-aged adults.

The cancer cells in NLPHL are large cells called popcorn cells. They are known as popcorn cells as they look like popcorns. Pop corn cells are lobular versions of Reed-Sternberg cells. Pop corn cells are also called lymphocytic and histiocytic (L&H) cells and they are variants of Reed-Sternberg cells.

NLPHL is more common in men than women. NLPHL grows more slowly and its treatment may be different from the classical type of Hodgkin’s lymphoma. It usually starts in lymph nodes in the neck and under the arm.

(10) What are the subtypes of Classic HL?
Classic Hodgkin’s lymphoma (CHL) has four subtypes:
(1) Nodular sclerosis Hodgkin’s lymphoma or NSCHL:
  1. This is the most common sub-type of classical Hodgkin lymphoma
  2. This is the most common type of Hodgkin’s disease in developed countries
  3. This type of classical Hodgkin’s lymphoma may cause fibrous scars in the lymph nodes.
  4. It can occur in people of any age and is more common in females
  5. NSCHL mostly affects children, teens, and young adults
  6. It is less frequently associated with Epstein-Barr virus
  7. Is most often found in lymph nodes in the chest and/or neck
  8. It accounts for about 7 out of 10 cases
(2) Mixed cellularity Hodgkin’s lymphoma or MCCHL:
  1. This is the second most common type most often found in the abdomen.
  2. Mixed cellularity is more common among older adults but is also found in children.
  3. This is found in about 4 out 10 cases and accounts for about 25% of all classical Hodgkin lymphoma cases.
  4. This type of Classical Hodgkin’s lymphoma is seen mostly in people with HIV infection.
  5. MCCHL can start in any lymph node but most often occurs in the upper half of the body.
(3) Lymphocyte-rich Hodgkin’s lymphoma:
  1. Lymphocyte rich accounts for 5 percent of all classical Hodgkin’s lymphoma cases.
  2. This sub-type of Hodgkin’s lymphoma is not much common.
  3. This is more often diagnosed in men.
  4. It usually occurs in the upper half of the body and is rarely found in more than a few lymph nodes.
(4) Lymphocyte-depleted Hodgkin’s lymphoma:
  1. This is a rare form of Hodgkin’s disease.
  2. Lymphocyte-depleted Hodgkin’s lymphoma is most often found in lymph nodes in the abdomen as well as in the liver, spleen, and bone marrow.
  3. It is most often diagnosed in older people or HIV infected people.
  4. This is the most aggressive than other types of Hodgkin’s lymphoma.
  5. Lymphocyte-depleted represents less than 1% of all Hodgkin lymphomas.

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